Maria Sakkari was ousted by Karolina Muchova in the second round at Roland Garros. (Tnani Badreddine/Getty Images)

Both Maria Sakkari and Emma Raducanu fell to their second-round opponents at the French Open on Wednesday, continuing a string of upsets in the tournament’s first three days.

With Sakkari out, five of the top 10 seeds have now been ousted from the tournament.

Karolina Muchova, currently ranked 81st in the world, fought hard against Sakkari, ranked No. 3, and ultimately prevailed 7-6 (7-5), 7-6 (7-4). She earned her sixth win over a top-10 opponent and fourth over a player ranked at No. 5 or higher.

Muchova will meet Amanda Anisimova in the third round after Anisimova took down Donna Vekic 6-4, 6-1 in the second round.

Aliaksandra Sasnovich once again played spoiler to Raducanu, 3-6, 6-1, 6-1. She had previously beaten Raducanu at Indian Wells – the teenager’s first match after winning the US Open as a qualifier.

Raducanu fought hard but ultimately fell flat. She lacked in the drop-shot, which Sasnovich utilized handedly to beat the world No. 12. Sasnovich hit 45 winners to 24 unforced errors compared to Raducanu’s 17 winners and 33 unforced errors.