Creighton's Rachael Saunders elevates for a shot in the second round against Iowa. (Keith Gillett/Icon Sportswire via Getty Images)

No. 10 seed Creighton is heading to the first Sweet 16 in program history after upsetting No. 2 Iowa 64-62 in the NCAA Tournament on Sunday.

The second-round matchup came down to the final possession, with Iowa unable to tie up the game after inbounding the ball with three seconds remaining on the clock. Creighton sophomore Lauren Jensen, an Iowa transfer, had a team-high 19 points, including the decisive 3-pointer to give the Bluejays the lead with 12.6 seconds left on the clock.

The Bluejays put the pressure on the Hawkeyes early, ending the first half with a 38-32 lead thanks to a 29-15 advantage on the boards. Creighton dominated on the boards the rest of the way, pulling down a total of 52 rebounds to Iowa’s 37.

Both teams struggled from the field, shooting just over 35 percent each. The Bluejays, however, had the upper hand from beyond the arc, making 10 of their 37 attempted 3-point shots, while Iowa went just 5-of-22 from deep. Creighton’s defense also shut down the Hawkeyes’ perimeter game, holding Caitlin Clark to just 15 points.

Iowa’s stunning second-round loss comes after the team clinched the Big Ten regular season and tournament title.

Creighton will meet the winner of No. 6 Georgia and No. 3 Iowa State in the Sweet 16 on Friday.