Former perennial contender Stanford basketball's 36-season NCAA tournament streak are likely over, as the unranked Cardinal fell out of the ACC tournament in the first round on Wednesday.

No. 14-seed Clemson delivered the 63-46 tournament-ending blow to No. 11-seed Stanford, who shot just 31.5% from the field to score their fewest points of the season.

"We’re not going to let this one game define us or who we are," said head coach Kate Paye. "We’re hopeful we get to continue to play, and we’re grateful for the opportunity to be here today."

March Madness chances dim with Stanford loss

While the NCAA basketball committee will have the final say on March 16th's Selection Sunday, the loss is a statistical death knell for Stanford's March Madness hopes, as the Cardinal drops to an underwhelming 16-14 record with Wednesday's loss.

Stanford has featured in every edition of the NCAA tournament since failing to advance in the 1986/87 season, racking up three national championships and 15 Final Four berths in that time.

The Cardinal holds the second-longest streak of appearances in the Big Dance, trailing only eight-time champion Tennessee, who have featured in every one of the NCAA's 42 tournaments.

The dramatic drop-off comes during a season of significant change for the Cardinal, who saw star Cameron Brink graduate into the WNBA, legendary head coach Tara VanDerveer retire after 38 seasons at the helm, and standout forward Kiki Iriafen transfer to USC last spring.

Even more, the dissolution of the Pac-12 had Stanford joining the ACC in last summer's conference realignment fray.

Rebuilds shape NCAA as top teams become 2024/25 underdogs

While the Cardinal experienced arguably the biggest upheaval since last season, they're far from the only top NCAA program enduring a rebuilding era.

After losing a handful of 2023/24 standouts, Stanford’s former Pac-12 foe Oregon State — who now competes in the West Coast Conference — faces slim national prospects after going unranked all season despite last year’s Elite Eight finish.

Similarly, back-to-back Final Four contenders Iowa also finds itself on shaky ground, taking the No. 11 seed in the steep Big Ten tournament as they strive to rebuild in the post-Caitlin Clark era.

All in all, the 2024/25 NCAA bracket will likely look a little different than in years past, as former March Madness shoo-ins struggle to find their footing amid graduating stars, heightened transfer portal activity, and conference realignment growing pains.

Iowa eyes bracket-busting March Madness run

Of all the rebuilding programs, Iowa is potentially the team most poised to make some noise during March Madness, with the Hawkeyes snagging some key ranked wins already this season — including last month’s upset of No. 2 USC.

With Clark’s alma mater aiming to bust brackets in the Big Dance, the Hawkeyes will use Wednesday's big 81-54 win over No. 14-seed Wisconsin to fuel them in Thursday's second round of the Big Ten tournament, where they'll face No. 6-seed Michigan State.

Earlier this season, Iowa fell in a slim 68-66 December loss to MSU, and the teams enter Thursday's matchup with nearly identical season records.

How to watch Thursday's NCAA conference tournament games

The unranked Hawkeyes will tip off against the No. 24-ranked Spartans at 9 PM ET. Live coverage will air on Fox Sports.