The NCAA Tournament begins Wednesday with the First Four, and the first round tips off Friday.

Yet while select teams rose to the top during the regular season, some of these will lose out in the tournament. Upsets happen, in spite of high seeding and home-court advantage. It be March Madness otherwise.

Just Women’s Sports takes a look at which top-4 teams are the most vulnerable.

No. 3 LSU

LSU may have finished their season at 28-2. But while the Tigers ran  amok in the SEC during the regular season, they have weaknesses.

For one, they couldn’t manage to hang with the No. 1 team in the nation in their February matchup against South Carolina. The game proved a failed test for an LSU team with a nonconference schedule chock-full of tough opponents such as… (checks notes) Bellarmine and Mississippi Valley.

Then Tigers ran into a roadblock in the SEC Tournament semifinals in Tennessee, which exposed LSU’s vulnerabilities and mounted an improbable comeback to advance to the title game. LSU faces Hawai’i in the first-round, and the Rainbow Warriors could be a tough test. And if LSU advances to the second round, it could face No. 6 seed Michigan, a battle-tested team coming out of the Big Ten.

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No. 4 Tennessee

In all likelihood, Tennessee will advance past No. 13 seed Saint Louis in the first round. But after that, the Vols could run up against No. 5 seed Iowa State. The Cyclones are not only Big 12 tournament champions, but they also boast star player Ashley Joens – who any team in this tournament will find difficult to contain.

Tennessee has its own star in Rickea Jackson, making the possibility of this second-round matchup very enticing. Still, it makes Tennessee susceptible to an early exit.

No. 3 Duke

There’s no telling what kind of run Duke will have in this year’s NCAA Tournament. Some thought that December’s win over NC State was the Blue Devils’ coming out party. But the ACC remained chaotic throughout the season, and Duke received its share of bumps and bruises – in particular, their 58-37 loss to Virginia Tech in the ACC Tournament might leave sour taste in the Blue Devils’ mouths as they prepare to face Iona in the first round.

But they’re also the team that put 68 points on Boston College while only allowing the Eagles to score 27. And they also beat Notre Dame back on Feb. 5. Their season-ending loss to UNC was redeemed by a win over the Tar Heels in the ACC Tournament, which showcases how hot and cold this team can be – particularly as they approached the end of the season.

If the Blue Devils can bring their best in the first and second rounds of the NCAA Tournament, they’ll be hard to beat. But there’s no guaranteeing that an Iona or a Colorado won’t send Duke packing.

No. 3 Notre Dame

Notre Dame is one of the biggest question marks in this year’s NCAA Tournament, as there’s no telling when they’ll get star player Olivia Miles back from injury – if they do at all.

And if Irish advance past Southern Utah in the first round, they’ll likely face Creighton in the second round. Yes, that Creighton, the same team that upended Iowa in the Sweet 16 last year. The same Creighton who almost beat UConn in February and battled against other top-tier Big East teams like Villanova and Marquette. A Notre Dame team with Olivia Miles going up against Creighton could be one of the best second-round matchups of the tournament. Without Miles, though, the Irish could head home early.

No. 2 UConn

Can UConn stay healthy? That’s the biggest question facing the Huskies in this year’s NCAA Tournament. If they can, then a run to the Final Four isn’t improbable, even in a tough region. Baylor could prove more difficult than anticipated, and Ohio State is a battle-tested No. 3 seed who has also faced injury issues this season but is also once again healthy.

Having Azzi Fudd and Caroline Ducharme back in the lineup helps the Huskies’ chances, and both looked good during the team’s Big East tournament title run. But as the story has been all season, there’s no telling what type of injury this team could face next.

Chelsea FC is once again looking across the pond to bolster their roster, with the six-time reigning WSL champions reportedly aiming to make a deal with NWSL side Angel City to acquire ACFC and USWNT forward Alyssa Thompson, per The Guardian this week.

Though the two clubs have yet to reach terms, Chelsea would need to have the deal signed before the WSL transfer window closes next Thursday.

Any agreement for Chelsea to snag Thompson from Angel City will likely feature yet another historic transfer fee, with cost projections topping former Tigres UANL star Lizbeth Ovalle's record $1.5 million transfer to the Orlando Pride earlier this month.

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The 20-year-old phenom is currently under contract with ACFC through the 2028 season after inking a three-year extension this past January.

With six goals and two assists in her 16 regular-season appearances in 2025 so far, the 2023 NWSL Draft No. 1 pick is trailing only rookie Riley Tiernan's seven goals on this year's Angel City scoresheet.

Should the transfer go through, Thompson would be the third ACFC player in a week to be moving to the UK, with the NWSL club transferring defender Alanna Kennedy and midfielder Katie Zelem to the newly WSL-promoted London City Lionesses on Wednesday.

As for Chelsea, the Blues have been a major player in recruiting US players over the last few seasons, with Thompson potentially joining her USWNT teammates Catarina Macario and Naomi Girma in suiting up for the WSL side's upcoming 2025/26 season.

Two-time US Open champion Naomi Osaka is looking like her old self this week, as the world No. 24 advanced to the 2025 New York Grand Slam's third round for the first time since 2021 with a straight-set win over the US's No. 47 Hailey Baptiste on Thursday.

"I don't make it my business to know anymore, I kind of just leave it up in the air," said the fan favorite following questions about a possible fifth Grand Slam title run. "I've trained really hard. I practiced really hard. If it happens, it happens."

After taking her lumps on the WTA Tour since returning from pregnancy in 2024, the 2025 US Open marks Osaka's first seeded entry into a major tournament since 2022 — and she appears to be embracing her competitive boost in style, complete with eye-catching outfits and a matching Labubu.

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The 27-year-old Japanese national next faces No. 18 Daria Kasatkina in the pair's third career meeting, with Osaka getting the best of the Australian in both previous matchups — most recently at the 2024 Italian Open.

Should Osaka advance to Sunday's Round of 16, she could be on a collision course toward a date with No. 3 Coco Gauff, after the US star advanced past her own emotionally challenging second-round battle on Thursday.

How to watch Naomi Osaka at the 2025 US Open

With times still to be announced, Osaka will next battle Kasatkina during the second day of 2025 US Open third-round play on Saturday.

Live coverage of the New York Grand Slam airs across ESPN platforms.

The No. 1 Kansas City Current have been unstoppable this season, riding a 10-match unbeaten streak into Saturday's game against the No. 9 North Carolina Courage and inching closer to claiming a franchise-first NWSL Shield.

The Current's dominant 12-point advantage over the No. 2 Washington Spirit marks the league's largest top-table margin since the Courage finished 15 points ahead in 2018.

Even more, Kansas City tops the NWSL in goals scored (34) while also registering the fewest goals allowed (10), entering the league's 18th weekend of play with a record-tying five consecutive shutouts.

After coming in fourth in 2024, the Current's defense has continued to improve under manager Vlatko Andonovski, while another MVP-level year from star forward Temwa Chawinga has bolstered Kansas City's offense.

Chawinga currently leads the 2025 NWSL Golden Boot race with 11 goals through 17 games, while sitting in the league's Top 3 for both shots and shots on goal.

"I think because we have such a powerful offense, the defensive things, maybe people don't notice as much," Kansas City forward Michelle Cooper said earlier this week. "I think something absolutely important to us is our entire back line and the commitment to get little touches in, to take [advantage] of angles, and block shots."

How to watch the Kansas City Current this weekend

No. 1 Kansas City will host No. 9 North Carolina — one of just two teams to defeat the Current all season — at 7:30 PM ET on Saturday, with live coverage airing on ION.

The No. 5 New York Liberty are creeping back up the ladder, as the defending WNBA champions continued reversing their recent skid with Thursday's 89-63 win over the No. 10 Washington Mystics — all while the race to the 2025 WNBA Playoffs reaches its boiling point.

While Washington rookie Sonia Citron's 18 points led the game, New York pulled together a true team effort to secure Thursday's victory, with five Liberty players scoring double-digits — including a season-high 16 points off the bench from forward Isabelle Harrison in her return from concussion protocol.

"We're not looking at the other teams at this point," Liberty forward Emma Meesseman said after the game. "We're just looking at ourselves, to maybe send a message to ourselves."

Despite that focus, New York is still contending with injury woes that have overshadowed much of the Liberty's season, taking Thursday's court without starters Sabrina Ionescu (toe), Jonquel Jones (illness), and Natasha Cloud (nose), while leaning on recently returned forward Breanna Stewart.

"We need to win the rest of our games," acknowledged Stewart, with the team gearing up for visits to the No. 4 Phoenix Mercury, No. 8 Golden State Valkyries, and No. 7 Seattle Storm over the next week. "We need to go and be road warriors."

The Liberty will have their hands full against the Mercury this weekend, with Phoenix coming in hot off a three-game winning streak with postseason-clinching top-of-mind.

"It's like a playoff matchup," Stewart added. "It's a big game, big implications, and [we're] not shying away from that."

How to watch the New York Liberty this weekend

No. 4 Phoenix will host No. 5 New York at 10 PM ET on Saturday, with live coverage airing on NBA TV.