The NCAA tournament tips off in earnest with the bracket's 64-team first round on Friday, as eager March Madness fans look beyond the chalk to eye the competition's underdogs after a rollercoaster 2024/25 basketball season.

Early upsets aren’t exactly the norm in the women’s tournament. Only one lower seed won their first-round matchup in 2024, and no team below a No. 3 seed has ever gone the distance, but in a season of increased parity, a few lower-rated squads are rounding into underdog form.

Harvard star Harmoni Turner dribbles during a 2023 game.
Harvard star Harmoni Turner could lead the Crimson to a first-round upset win. (Erica Denhoff/Icon Sportswire via Getty Images)

Breaking down potential March Madness bracket-busters

For potential March Madness upset instigators, late-season momentum late season momentum is the name of the game — a dangerous factor in any single-elimination tournament.

Even without superstar grad Caitlin Clark, No. 6-seed Iowa capped their regular season on a high before narrowly losing to No. 4-seed Ohio State in the Big Ten tournament's quarterfinals. Should they advance past No. 11-seed Murray State in their first-round Saturday matchup, the Hawkeyes are poised to give No. 3-seed Oklahoma a run for their money in the second round on Monday.

Entering as a No. 10-seed, Ivy League tournament champs Harvard will have their hands full against No. 7-seed Michigan State on Saturday, but Crimson senior Harmoni Turner and her season-average 22.5 points per game could tilt the scales in Harvard's favor.

After edging out first-round opponent No. 11-seed Iowa State, No. 6-seed Michigan is playing like an upset contender. Now a potential second-round matchup against No. 3-seed Notre Dame — fresh off a recent losing skid — awaits the young squad. 

With the brackets locked and the teams loaded, the prospects of twists and turns make the first two rounds of the NCAA tournament especially exciting — even if this year’s frontrunners appear destined for Tampa.

Michigan basketball's Syla Swords listens in a team huddle.
No. 6 Michigan will battle fellow Madness underdog No. 11 Iowa State in the tournament's Friday opener. (Michael Hickey/Getty Images)

How to watch Women's March Madness games this weekend

The Big Dance officially begins at 11:30 AM ET on Friday, when No. 11 Iowa State tips off against No. 6 Michigan on ESPN2.

Saturday's slate will complete the 2024/25 NCAA tournament's first round, with No. 6 Iowa beginning their Madness run against No. 11 Murray State at 12 PM ET on ESPN.

No. 10 Harvard will start dancing a few hours later, with the Crimson facing No. 7 Michigan State at 4:30 PM ET on ESPNews.

All games in the 2025 March Madness tournament will have live coverage across ESPN networks.